JOHN GABRIELI (2016-04-01 to 2017-03-31) Upgrade to 3 Tesla MRI scanner for brain imaging at MIT. Amount: $600000
? The Martinos Imaging Center at MIT is a core facility that provides researchers with access to cutting-edge brain imaging technologies, including magnetic resonance imaging (MRI), magnetoencephalography (MEG), electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS). The Center has two Siemens Magnetom Trio 3T MRI scanners, one of which is almost ten years old and approaching the end of its expected lifespan. We propose to upgrade this instrument with Siemens' Prisma technology, which will greatly enhance its capabilities and life expectancy. In particular, this upgrade, branded by Siemens as Prisma-fit, will greatly improve the quality of diffusion imaging and will also provide better signal/noise in other imaging modalities, along with better instrument stability, lower acoustic noise, and shorter scan times. Moreover, because the upgrade involves complete replacement of the gradient coils, the life expectancy of the instrument will also be prolonged, essentially to that of a brand new scanner. The upgraded scanner will support research by multiple groups of users, including the 15 principle investigators (PIs) listed in this proposal. These researchers are conducting studies in many areas of basic and clinical neuroscience, including studies of brain function in healthy subjects, its development in children, and its disruption in many different brain disorders. In particular, NIH-funded projects by major users on this proposal include studies of autism, dyslexia, attention, social cognition, color vision, scene perception, and the anatomical structure and development of the human brain. Additional projects focus on schizophrenia, traumatic brain injury, auditory perception and hearing loss, and the development of new MRI-based technologies. In addition to human neuroimaging, the upgraded scanner will also be advantageous for many studies on animal models, allowing us to draw new parallels between mechanistic animal studies and human brain function. In sum, the upgraded MRI scanner will support a large and highly productive group of users, enabling them to remain at the forefront of neuroimaging research for many years into the future.
？麻省理工学院的Martinos成像中心是一个核心设施，为研究人员提供先进的脑成像技术，包括磁共振成像（MRI），脑磁图（MEG），脑电图（EEG）和功能性近红外光谱（fNIRS）。该中心有两台Siemens Magnetom Trio 3T MRI扫描仪，其中一台已有近十年的历史，接近其预期使用寿命。我们建议使用西门子的Prisma技术升级该仪器，这将大大提高其功能和预期寿命。特别是，这项升级，由西门子品牌为Prisma-fit，将极大地提高扩散成像的质量，并在其他成像模式中提供更好的信号/噪声，以及更好的仪器稳定性，更低的声学噪声和更短的扫描时间。此外，由于升级涉及完全更换梯度线圈，因此仪器的预期寿命也将延长，基本上与全新扫描仪的预期寿命相比。升级后的扫描仪将支持多组用户的研究，包括本提案中列出的15个主要调查员（PI）。这些研究人员正在基础和临床神经科学的许多领域进行研究，包括健康受试者的脑功能研究，儿童的发育以及许多不同脑部疾病的破坏。特别是，NIH资助的主要用户项目包括自闭症，阅读障碍，注意力，社会认知，色觉，场景感知以及人脑的解剖结构和发展。其他项目的重点是精神分裂症，创伤性脑损伤，听觉感知和听力损失，以及基于MRI的新技术的发展。除了人类神经成像之外，升级的扫描仪对于动物模型的许多研究也将是有利的，这使我们能够在机械动物研究和人类大脑功能之间找到新的相似之处。总而言之，升级后的MRI扫描仪将支持庞大且高效的用户群，使他们能够在未来多年保持神经影像研究的最前沿。
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