fNIRS System to Further Research on Neurodevelopmental Disorders

fNIRS系统进一步研究神经发育障碍

KEVIN PELPHREY (2010-07-17 to 2011-10-16) $444,700

Project ID: S10RR026823 (NCRR)

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Abstract

This proposal seeks support to acquire a state-of-the-art Hitachi Medical Systems ETG-4000 functional near infrared spectroscopy (fNIRS) multi-channel optical topography system for the study of the brain systems underpinning various aspects of human cognitive and social functioning, as well as their typical and atypical development across the lifespan, from early infancy to late adulthood. Clinical and basic scientists from multiple disciplines and departments at Yale University stand poised to use the proposed brain imaging system to make field-leading contributions in the context of furthering their National Institutes of Health-funded, translational research programs. These research programs address critical questions in a number of important areas including the cognitive neuroscience of autism, developmental cognitive neuroscience, developmental psychopathology, aspects of high-level cognition including memory and executive control, visual cognition, neuroimaging methods development, and social neuroscience. Scientists at Yale University have been at the forefront of advances in neuroimaging techniques, particularly as they are applied to understanding the human mind and its development. While much progress has been made, fundamental questions about typical and atypical brain function remain to be addressed with the help of the requested instrument.

该提案寻求支持获得最先进的日立医疗系统ETG-4000功能性近红外光谱（fNIRS）多通道光学地形系统，用于研究支撑人类认知和社会功能各个方面的大脑系统，从婴儿早期到成年后期，它们在整个生命周期中的典型和非典型发展。来自耶鲁大学多个学科和系的临床和基础科学家们准备使用所提出的脑成像系统，在推进其国立卫生研究院资助的转化研究项目的背景下做出领先的贡献。这些研究项目涉及许多重要领域的关键问题，包括自闭症的认知神经科学，发育认知神经科学，发育性精神病理学，高级认知方面，包括记忆和执行控制，视觉认知，神经影像学方法发展和社会神经科学。耶鲁大学的科学家一直处于神经影像技术进步的最前沿，特别是当它们被用于理解人类思维及其发展时。虽然取得了很大进展，但在所要求的文书的帮助下，有关典型和非典型脑功能的基本问题仍有待解决。