Insulin and Autophagy in Neurodegeneration

de Mello, Orellana, Mazucanti, de Morais Lima, Scavone, Kawamoto (2019) Insulin and Autophagy in Neurodegeneration Front Neurosci (IF: 4.3) 13 491
Full Text
Full text

Click the PDF icon to view the full text of the paper

Abstract

Crosstalk in the pathophysiological processes underpinning metabolic diseases and neurodegenerative disorders have been the subject of extensive investigation, in which insulin signaling and autophagy impairment demonstrate to be a common factor in both conditions. Although it is still somewhat conflicting, pharmacological and genetic strategies that regulate these pathways may be a promising approach for aggregate protein clearancing and consequently the delaying of onset or progression of the disease. However, as the response due to this modulation seems to be time-dependent, finding the right regulation of autophagy may be a potential target for drug development for neurodegenerative diseases. In this way, this review focuses on the role of insulin signaling/resistance and autophagy in some neurodegenerative diseases, discussing pharmacological and non-pharmacological interventions in these diseases.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558407
http://www.ncbi.nlm.nih.gov/pubmed/31231176
http://dx.doi.org/10.3389/fnins.2019.00491

Similar articles

Tools