Insulin and Autophagy in Neurodegeneration
de Mello, Orellana, Mazucanti, de Morais Lima, Scavone, Kawamoto (2019) Insulin and Autophagy in Neurodegeneration Front Neurosci (IF: 4.3) 13 491Abstract
Crosstalk in the pathophysiological processes underpinning metabolic diseases and neurodegenerative disorders have been the subject of extensive investigation, in which insulin signaling and autophagy impairment demonstrate to be a common factor in both conditions. Although it is still somewhat conflicting, pharmacological and genetic strategies that regulate these pathways may be a promising approach for aggregate protein clearancing and consequently the delaying of onset or progression of the disease. However, as the response due to this modulation seems to be time-dependent, finding the right regulation of autophagy may be a potential target for drug development for neurodegenerative diseases. In this way, this review focuses on the role of insulin signaling/resistance and autophagy in some neurodegenerative diseases, discussing pharmacological and non-pharmacological interventions in these diseases.
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6558407http://www.ncbi.nlm.nih.gov/pubmed/31231176
http://dx.doi.org/10.3389/fnins.2019.00491