A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation

Wu, Hu, Wang, Shao, Zhao, Bai, Huang, Tang, Liang (2019) A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation Chem Commun (Camb) (IF: -1) 55(63) 9363-9366

Abstract

We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.

Links

http://www.ncbi.nlm.nih.gov/pubmed/31317136
http://dx.doi.org/10.1039/c9cc03846a

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