Keeping the autophagy tempo

Pastore, Ballabio (2019) Keeping the autophagy tempo Autophagy (IF: 13.3) 15(10) 1854-1856
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Abstract

Most essential physiological functions in mammals show a 24-h rhythmic pattern, which includes sleep-wake, feeding-non-feeding cycles and energy metabolism. Recent studies indicate that macroautophagy/autophagy also displays a robust circadian rhythmicity following the daily feeding pattern in adult mammals. We discovered that MiT-TFE transcription factors TFEB and TFE3, master regulators of autophagy and lysosomal biogenesis, are activated in a circadian manner and drive the expression of NR1D1/REV-ERBα, a key component of the core clockwork, thus revealing a molecular link between the nutrient-driven circadian cycle and the light-induced molecular clock. The dynamic balance between TFEB and TFE3 activation and NR1D1 expression is responsible for the modulation and oscillation of autophagy and metabolism genes.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6735489
http://www.ncbi.nlm.nih.gov/pubmed/31318631
http://dx.doi.org/10.1080/15548627.2019.1645545

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