A bioinformatics analysis of exosomal microRNAs released following mycobacterial infection
Alipoor, Adcock, Folkerts, Garssen, Mortaz (2019) A bioinformatics analysis of exosomal microRNAs released following mycobacterial infection Int J Mycobacteriol (IF: -1) 8(3) 218-222Abstract
Tuberculosis (TB) still remains a major health threat worldwide. The current TB diagnostics are suboptimal, and there is a high clinical need for identifying novel biomarkers of disease prevalence. Circulating exosomes have been currently attractive as novel biomarkers in a wide range of pathological conditions.In this study, we performed bioinformatics analysis on the downstream targets of a dysregulated microRNA (miRNA) cluster induced by Bacillus Calmette-Guerin infection of human macrophages to provide greater understanding of their potential roles in disease pathogenesis.Our analysis demonstrated that these dysregulated miRNAs have central roles in the host metabolic and energy pathways.This suggests that the host miRNA network is perturbed by Mycobacterium to re-patterning host metabolism machinery to favor its intracellular survival. The dysregulated miRNAs can be delivered to local and distal cells by exosomes and thereby modulate their function.
Links
http://www.ncbi.nlm.nih.gov/pubmed/31512596http://dx.doi.org/10.4103/ijmy.ijmy_88_19
