Immunophenotypic Analysis of CAR-T Cells

de Azevedo, Mizukami, Moço, Malmegrim (2020) Immunophenotypic Analysis of CAR-T Cells Methods Mol Biol (IF: -1) 2086 195-201

Abstract

CAR-T cell immunotherapy is a promising therapeutic modality for cancer patients. The success of CAR-T cell therapy has been associated with the phenotype, activation and functional profiling of infused CAR-T cells. Therefore, immunophenotypic characterization of CAR-T cells during bioprocess is crucial for cell quality control and ultimately for improved antitumor efficacy. In this chapter, we propose a flow cytometry panel to characterize the immunophenotype of the CAR-T subsets.

Links

http://www.ncbi.nlm.nih.gov/pubmed/31707677
http://dx.doi.org/10.1007/978-1-0716-0146-4_14

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