Characteristics of Allosteric Proteins, Sites, and Modulators
He, Ni, Lu, Zhang (2019) Characteristics of Allosteric Proteins, Sites, and Modulators Adv Exp Med Biol (IF: 3.7) 1163 107-139Abstract
Allostery is considered one of the most direct and efficient ways to regulate biological macromolecule functions. Allostery is increasingly receiving attention in the field of drug discovery because of the unique advantages of allosteric modulators such as high selectivity and low toxicity. Because of technical breakthroughs in the allosteric studies, the understanding of the characteristics of allosteric entities such as allosteric proteins and their allosteric sites and modulators has made great strides. These features play a critical role in both the evolution of the allosteric concept and the prediction of allosteric interactions. In this chapter, we highlight the fundamental characteristics of allosteric proteins, allosteric sites, and allosteric modulators. Importantly, the applications of such principles in real cases are depicted in detail. Collectively, these characteristics are beneficial in aiding allosteric drug design and allosteric mechanism research.
Links
http://www.ncbi.nlm.nih.gov/pubmed/31707702http://dx.doi.org/10.1007/978-981-13-8719-7_6
