DIMERBOW: exploring possible GPCR dimer interfaces
García-Recio, Navarro, Franco, Olivella, Guixà-González, Cordomí (2020) DIMERBOW: exploring possible GPCR dimer interfaces Bioinformatics (IF: 5.8) 36(10) 3271-3272Abstract
G protein-coupled receptors (GPCRs) can form homo-, heterodimers and larger order oligomers that exert different functions than monomers. The pharmacological potential of such complexes is hampered by the limited information available on the type of complex formed and its quaternary structure. Several GPCR structures in the Protein Data Bank display crystallographic interfaces potentially compatible with physiological interactions.Here, we present DIMERBOW, a database and web application aimed to visually browse the complete repertoire of potential GPCR dimers present in solved structures. The tool is suited to help finding the best possible structural template to model GPCR homomers.DIMERBOW is available at http://lmc.uab.es/dimerbow/.Supplementary data are available at Bioinformatics online.© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Links
http://www.ncbi.nlm.nih.gov/pubmed/32096817http://dx.doi.org/10.1093/bioinformatics/btaa117
