The ARF/p53 pathway
Sherr, Weber (2000) The ARF/p53 pathway Curr Opin Genet Dev (IF: 3.7) 10(1) 94-9Abstract
The ARF tumor suppressor connects pathways regulated by the retinoblastoma protein and p53. ARF inactivation reduces p53-dependent apoptosis induced by oncogenic signals. Nucleolar relocalization of Mdm2 by ARF connotes a novel mechanism for preventing p53 turnover and provides a framework for understanding how stress signals cooperate to regulate p53 function.
Links
http://www.ncbi.nlm.nih.gov/pubmed/10679383http://dx.doi.org/10.1016/s0959-437x(99)00038-6
