The TIM-barrel fold: a versatile framework for efficient enzymes
Wierenga (2001) The TIM-barrel fold: a versatile framework for efficient enzymes FEBS Lett (IF: 3) 492(3) 193-8Abstract
Recent studies on triosephosphate isomerase (TIM)-barrel enzymes highlight the remarkable versatility of the TIM-barrel scaffold. At least 15 distinct enzyme families use this framework to generate the appropriate active site geometry, always at the C-terminal end of the eight parallel beta-strands of the barrel. Sequence and structure comparisons now suggest that many of the TIM-barrel enzymes are evolutionarily related. Common structural properties of TIM-barrel enzymes are discussed.
Links
http://www.ncbi.nlm.nih.gov/pubmed/11257493http://dx.doi.org/10.1016/s0014-5793(01)02236-0
