Application of PNA and LNA oligomers to chemotherapy
Elayadi, Corey (2001) Application of PNA and LNA oligomers to chemotherapy Curr Opin Investig Drugs (IF: 0) 2(4) 558-61Abstract
Peptide nucleic acid (PNA) and locked nucleic acid (LNA) oligomers bind to complementary sequences with extremely high affinity. This high-affinity binding supports the hypothesis that they have advantages for targeting cellular nucleic acids and provide a better route for the development of oligonucleotide-based antiproliferative drugs. This article reviews the properties of PNA and LNA oligomers and describes the challenges that confront their application to cancer therapy.
