A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction
Evans, Seidel, Rueping, Lam, Shaw, Downey (2003) A new copper acetate-bis(oxazoline)-catalyzed, enantioselective Henry reaction J Am Chem Soc (IF: 15.6) 125(42) 12692-3Abstract
A highly enantioselective, nitroaldol reaction catalyzed by a chiral Cu(II) bis(oxazoline) complex has been developed. The reaction scope includes both aromatic and aliphatic aldehydes (15 examples) affording products in good yields and enantioselectivities (87-94% ee). An X-ray structure of the catalyst has been provided along with a rationalization of the sense of asymmetric induction.
Links
http://www.ncbi.nlm.nih.gov/pubmed/14558801http://dx.doi.org/10.1021/ja0373871
