Antiproliferative hopane and oleanane glycosides from the roots of Glinus lotoides

Arafa Hamed, Sonia Piacente, Giuseppina Autore, Stefania Marzocco, Cosimo Pizza, Wieslaw Oleszek (2005) Antiproliferative hopane and oleanane glycosides from the roots of Glinus lotoides Planta Med (IF: 2) 71(6) 554-60

Abstract

Three new hopane saponins, lotoidosides A - C (1 - 3), and four new oleanane saponins, lotoidosides D - G (4 - 7), were isolated from the roots of Glinus lotoides L. (Molluginaceae). Their structures were determined by extensive 1D- and 2D-NMR spectroscopy and ESI-MS analysis. The antiproliferative activity of compounds 1 - 7 was evaluated using three continuous murine and human culture cell lines J774.A1, HEK-293, WEHI-164. Compounds 1 and 3 - 7 showed significant cytotoxicity against the three cancer cell lines with IC50 values ranging from 0.018 to 0.62 microM, while compound 2 exerted a weak activity only against the cell line HEK-293.

Links

http://www.ncbi.nlm.nih.gov/pubmed/15971128
http://dx.doi.org/10.1055/s-2005-864158

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