4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity
Sparatore, Basilico, Parapini, Romeo, Novelli, Sparatore, Taramelli (2005) 4-Aminoquinoline quinolizidinyl- and quinolizidinylalkyl-derivatives with antimalarial activity Bioorg Med Chem (IF: 3.3) 13(18) 5338-45Abstract
A set of quinolizidinyl and quinolizidinylalkyl derivatives of 4-amino-7-chloroquinoline and of 9-amino-6-chloro-2-methoxyacridine were prepared and tested in vitro against CQ-sensitive (D-10) and CQ-resistant (W-2) strains of Plasmodium falciparum. All compounds but one exerted significant antimalarial activity. Some of the quinolizidine derivatives were from 5 to 10 times more active than chloroquine on the CQ-resistant strain. No toxicity against mammalian cells was observed.
Links
http://www.ncbi.nlm.nih.gov/pubmed/16054368http://dx.doi.org/10.1016/j.bmc.2005.06.047
