NF-kappaB activation in melanoma

Ueda, Richmond (2006) NF-kappaB activation in melanoma Pigment Cell Res (IF: -1) 19(2) 112-24

Abstract

Metastatic melanoma is an aggressive skin cancer that is notoriously resistant to current cancer therapies. In human melanoma, nuclear factor-kappa B (NF-kappaB) is upregulated, leading to the deregulation of gene transcription. In this review, we discuss (i) the relationship between gene alteration in melanoma and upregulation of NF-kappaB, (ii) mechanisms by which activated NF-kappaB switch from pro-apoptotic to anti-apoptotic functions in melanoma and (iii) autocrine mechanisms that promote constitutive activation of NF-kappaB in metastatic melanoma.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2668252
http://www.ncbi.nlm.nih.gov/pubmed/16524427
http://dx.doi.org/10.1111/j.1600-0749.2006.00304.x

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