Moss bioreactors producing improved biopharmaceuticals
Decker, Reski (2007) Moss bioreactors producing improved biopharmaceuticals Curr Opin Biotechnol (IF: 7.1) 18(5) 393-8Abstract
Plants may serve as superior production systems for complex recombinant pharmaceuticals. Current strategies for improving plant-based systems include the development of large-scale production facilities as well as the optimisation of protein modifications. While post-translational modifications of plant proteins generally resemble those of mammalian proteins, certain plant-specific protein-linked sugars are immunogenic in humans, a fact that restricts the use of plants in biopharmaceutical production so far. The moss Physcomitrella patens was developed as a contained tissue culture system for recombinant protein production in photo-bioreactors. By targeted gene replacements, moss strains were created with non-immunogenic humanised glycan patterns. These were proven to be superior to currently used mammalian cell lines in producing antibodies with enhanced effectiveness.
Links
http://www.ncbi.nlm.nih.gov/pubmed/17869503http://dx.doi.org/10.1016/j.copbio.2007.07.012
