Cytochrome c: functions beyond respiration
Ow, Green, Hao, Mak (2008) Cytochrome c: functions beyond respiration Nat Rev Mol Cell Biol (IF: 81) 9(7) 532-42Abstract
Cytochrome c is primarily known for its function in the mitochondria as a key participant in the life-supporting function of ATP synthesis. However, when a cell receives an apoptotic stimulus, cytochrome c is released into the cytosol and triggers programmed cell death through apoptosis. The release of cytochrome c and cytochrome-c-mediated apoptosis are controlled by multiple layers of regulation, the most prominent players being members of the B-cell lymphoma protein-2 (BCL2) family. As well as its role in canonical intrinsic apoptosis, cytochrome c amplifies signals that are generated by other apoptotic pathways and participates in certain non-apoptotic functions.
Links
http://www.ncbi.nlm.nih.gov/pubmed/18568041http://dx.doi.org/10.1038/nrm2434
