Impact of MHC class I diversity on immune control of immunodeficiency virus replication

Goulder, Watkins (2008) Impact of MHC class I diversity on immune control of immunodeficiency virus replication Nat Rev Immunol (IF: 60.9) 8(8) 619-30

Abstract

The recent failure of the T-cell-based HIV vaccine trial led by Merck & Co., Inc. prompts the urgent need to refocus on the question of which T-cell responses are required to control HIV replication. The well-described association between the expression of particular MHC class I molecules and successful containment of HIV or, in the macaque model, SIV replication provide a valuable starting point from which to evaluate more precisely what might constitute effective CD8(+) T-cell responses. Here, we review recent studies of T-cell-mediated control of HIV and SIV infection, and offer insight for the design of a successful T-cell-based HIV vaccine in the future.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2963026
http://www.ncbi.nlm.nih.gov/pubmed/18617886
http://dx.doi.org/10.1038/nri2357

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