Role of PD-1 in regulating T-cell immunity
Jin, Ahmed, Okazaki (2011) Role of PD-1 in regulating T-cell immunity Curr Top Microbiol Immunol (IF: 4.7) 350 17-37Abstract
Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals upon interaction with its two ligands, PD-L1 or PD-L2. PD-1 and its ligands are broadly expressed and exert a wider range of immunoregulatory roles in T cells activation and tolerance compared with other CD28 members. Subsequent studies show that PD-1-PD-L interaction regulates the induction and maintenance of peripheral tolerance and protect tissues from autoimmune attack. PD-1 and its ligands are also involved in attenuating infectious immunity and tumor immunity, and facilitating chronic infection and tumor progression. The biological significance of PD-1 and its ligand suggests the therapeutic potential of manipulation of PD-1 pathway against various human diseases. In this review, we summarize our current understanding of PD-1 and its ligands ranging from discovery to clinical significance.
Links
http://www.ncbi.nlm.nih.gov/pubmed/21061197http://dx.doi.org/10.1007/82_2010_116
