Septins at the annulus of mammalian sperm

Aminata Toure, Baptiste Rode, Gary Hunnicutt, Denise Escalier, Gérard Gacon (2011) Septins at the annulus of mammalian sperm Biol Chem (IF: 2.4) 392(8-9) 799-803

Abstract

The annulus is an electron-dense ring structure connecting the midpiece and the principal piece of the mammalian sperm flagellum. Proteins from the septin family have been shown to localize to the annulus. A septin complex is assembled early in spermiogenesis with the cochaperone DNAJB13 and, in mature sperm, associates with Testis Anion Transporter 1; SLC26A8 (Tat1), a transmembrane protein of the SLC26 family. Studies in mice have shown that the annulus acts as a barrier to protein diffusion and controls correct organization of the midpiece. Consistent with these findings, absence of the annulus is associated with flagellum differentiation defects and asthenozoospermia in humans.

Links

http://www.ncbi.nlm.nih.gov/pubmed/21740329
http://dx.doi.org/10.1515/BC.2011.074

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