Bio-based production of the platform chemical 1,5-diaminopentane
Stefanie Kind, Christoph Wittmann (2011) Bio-based production of the platform chemical 1,5-diaminopentane Appl Microbiol Biotechnol (IF: 4.3) 91(5) 1287-96Abstract
In the rising era of bio-economy, the five carbon compound 1,5-diaminopentane receives increasing interest as platform chemical, especially as innovative building block for bio-based polymers. The vital interest in bio-based supply of 1,5-diaminopentane has strongly stimulated research on the development of engineered producer strains. Based on the state-of-art knowledge on the pathways and reactions linked to microbial 1,5-diaminopentane metabolism, the review covers novel systems metabolic engineering approaches towards hyper-producing cell factories of Corynebacterium glutamicum or Escherichia coli. This is integrated into the whole value chain from renewable feedstocks via 1,5-diaminopentane to innovative biopolymers involving bioprocess engineering considerations for economic supply.
Links
http://www.ncbi.nlm.nih.gov/pubmed/21761208http://dx.doi.org/10.1007/s00253-011-3457-2
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