Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions

Mehta, Abdelwahed, Mahanta, Fedoseyenko, Philmus, Cooper, Liu, Jhulki, Ealick, Begley (2015) Radical S-adenosylmethionine (SAM) enzymes in cofactor biosynthesis: a treasure trove of complex organic radical rearrangement reactions J Biol Chem (IF: 4) 290(7) 3980-6

Abstract

In this minireview, we describe the radical S-adenosylmethionine enzymes involved in the biosynthesis of thiamin, menaquinone, molybdopterin, coenzyme F420, and heme. Our focus is on the remarkably complex organic rearrangements involved, many of which have no precedent in organic or biological chemistry.© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326808
http://www.ncbi.nlm.nih.gov/pubmed/25477515
http://dx.doi.org/10.1074/jbc.R114.623793

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