Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases

Martinez, Hausinger (2015) Catalytic Mechanisms of Fe(II)- and 2-Oxoglutarate-dependent Oxygenases J Biol Chem (IF: 4) 290(34) 20702-20711

Abstract

Mononuclear non-heme Fe(II)- and 2-oxoglutarate (2OG)-dependent oxygenases comprise a large family of enzymes that utilize an Fe(IV)-oxo intermediate to initiate diverse oxidative transformations with important biological roles. Here, four of the major types of Fe(II)/2OG-dependent reactions are detailed: hydroxylation, halogenation, ring formation, and desaturation. In addition, an atypical epimerization reaction is described. Studies identifying several key intermediates in catalysis are concisely summarized, and the proposed mechanisms are explained. In addition, a variety of other transformations catalyzed by selected family members are briefly described to further highlight the chemical versatility of these enzymes.© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4543632
http://www.ncbi.nlm.nih.gov/pubmed/26152721
http://dx.doi.org/10.1074/jbc.R115.648691

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