Chimeric antigen receptor T-cell therapy for cancer: a basic research-oriented perspective
Chungyong Han, Byoung Kwon (2018) Chimeric antigen receptor T-cell therapy for cancer: a basic research-oriented perspective Immunotherapy (IF: 2.3) 10(3) 221-234Abstract
Chimeric antigen receptor (CAR) T cells have outstanding therapeutic potential for treating blood cancers. The prospects for this technology have accelerated basic research, clinical translation and Big Pharma's investment in the field of T-cell therapeutics. This interest has led to the discovery of key factors that affect CAR T-cell efficacy and play pivotal roles in T-cell immunology. Herein, we introduce advances in adoptive immunotherapy and the birth of CAR T cells, and review CAR T-cell studies that focus on three important features: CAR constructs, target antigens and T-cell phenotypes. At last, we highlight novel strategies that overcome the tumor microenvironment and circumvent CAR T-cell side effects, and consider the future direction of CAR T-cell development.
Links
http://www.ncbi.nlm.nih.gov/pubmed/29370727http://dx.doi.org/10.2217/imt-2017-0133
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