Cachau, Zhu, Nicklaus (2019) The upcoming subatomic resolution revolution Current opinion in structural biology 58() 53-58

Abstract

Subatomic resolution macromolecular crystallography has been revealing the most fascinating details of macromolecular structures for many years. This most extreme form of macromolecular crystallography is going through rapid changes. A new generation of superbrilliant X-ray sources and detectors is facilitating the rapid acquisition of high-quality datasets. Equally important, a new breed of methods and highly integrated advanced computational tools for structure refinement and analysis is poised to change the way we use subatomic resolution data and reposition high-resolution macromolecular crystallography in medicinal chemistry studies. Subatomic resolution macromolecular crystallography may soon be a routine source of detailed molecular information besides precise geometries, including binding energies and other chemical descriptors, opening new possibilities of application. Copyright © 2019 Elsevier Ltd. All rights reserved.

Links

http://www.ncbi.nlm.nih.gov/pubmed/31233975
http://dx.doi.org/10.1016/j.sbi.2019.05.013

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