Wang, Xu, Mu, Han, Liu, Feng, Zhang, Yuan (2019) Fe doped copper sulfide nanoparticles for in vivo magnetic resonance imaging and simultaneous photothermal therapy Nanotechnology ()


Multifunctional theranostic agents are widely applied in cancer diagnosis and treatment. These agents can significantly improve therapeutic outcomes and reduce adverse effects in current cancer therapy. Here, we designed and synthesized iron ions doped copper sulfide nanoparticles with polyvinylpyrollidone (FCS @PVP NPs) for magnetic resonance imaging (MRI) guided photothermal therapy. The biocompatible FCS@PVP NPs with strong near-infrared absorption could be used as the photothermal agent and the magnetic characteristic of Fe3+ ions could be applied for T1-weighted magnetic resonance imaging (MRI). The T1-weighted MRI, high photothermal performance, and the biodistribution of FCS@PVP NPs were investigated in mice after intravenous administration. The data showed that there was high accumulation of FCS@PVP NPs in the tumor site because of the enhanced permeability and retention (EPR) effect. This result also indicated that the tumors in tumor-bearing mice were effectively suppressed after FCS@PVP NPs treatment under 808 nm laser irradiation. More importantly, FCS@PVP NPs show low cytotoxicity and low side effects because of the quick and safe elimination through hepatobiliary/fecal route. This work provided a foundation for the clinical application of FCS@PVP NPs as a promising multifunctional theranostic agent for MRI guided photothermal therapy of cancer. © 2019 IOP Publishing Ltd.