The importance of CT quantitative evaluation of emphysema in lung cancer screening cohort with negative findings by visual evaluation
Li, Xia, Fang, Guan, Wang, Liu, Fan (2019) The importance of CT quantitative evaluation of emphysema in lung cancer screening cohort with negative findings by visual evaluation Clin Respir J (IF: 1.7) 13(12) 741-750Abstract
One-stop quantitative evaluation of emphysema and lung nodule in lung cancer screening is very important for patient.To evaluate the quantitative emphysema in the large-sample low-dose CT lung cancer screening cohort with negative CT findings by subjective visual assessment.One thousand, two hundred and thirty-one participants with negative visual evaluation were included in this retrospective study. The lungs were automatically segmented and the following were calculated: total lung volume (TLV), total emphysema volume (TEV), emphysema index (EI), 15th percentile lung density and mean lung density. EI ≥6% was defined as emphysema. The quantitative parameters were compared between different genders and ages. The quantitative parameters and risk factors were compared between emphysema and non-emphysema groups.The proportion of smokers, TLV, TEV and EI of men were greater than that of women (P < 0.001). No correlation was found between age and volumes; the TEV and EI of people older than 60 years were greater than those younger than 60 years (P < 0.05) by age categorisation. One hundred and two participants showed emphysema, accounting for 8.29%. The incidence of emphysema in men was greater than that in women in total (P < 0.05). All the CT quantitative parameters were significantly different between emphysema and non-emphysema groups. The ratio of male, secondhand smoke exposure and chronic bronchitis history was greater in emphysema than that in the non-emphysema group (P < 0.05).CT quantitative emphysema evaluation is recommended in people older than 60 years, especially in males, providing more precise information, aiding the early diagnosis of emphysema and informing early intervention.© 2019 John Wiley & Sons Ltd.
Links
http://www.ncbi.nlm.nih.gov/pubmed/31444943http://dx.doi.org/10.1111/crj.13084
