Li, Xia, Fang, Guan, Wang, Liu, Fan (2019) The Importance of CT Quantitative Evaluation of Emphysema in Lung Cancer Screening Cohort with Negative Findings by Visual Evaluation The clinical respiratory journal ()


One-stop quantitative evaluation of emphysema and lung nodule in lung cancer screening is very important for patient. To evaluate the quantitative emphysema in the large-sample LDCT lung cancer screening cohort with negative CT findings by subjective visual assessment. 1231 participants with negative visual evaluation were included in this retrospective study. The lungs were automatically segmented and the following were calculated: total lung volume (TLV), total emphysema volume (TEV), emphysema index (EI) ,15th percentile lung density (PD15) and mean lung density (MLD). EI ≥ 6% was defined as emphysema. The quantitative parameters were compared between different genders and ages. The quantitative parameters and risk factors were compared between emphysema and non-emphysema groups. The proportion of smokers, TLV, TEV, and EI of men were greater than that of women(P<0.001). No correlation was found between age and volumes; the TEV and EI of people older than 60 years were greater than those younger than 60 years (P<0.05) by age categorization. 102 participants showed emphysema, accounting for 8.29%. The incidence of emphysema in men was greater than that in women in total (P<0.05). All the CT quantitative parameters were significantly different between emphysema and non-emphysema groups. The ratio of male, second hand smoke exposure and chronic bronchitis history was greater in emphysema than that in the non-emphysema group (P<0.05). CT quantitative emphysema evaluation is recommended in people older than 60 years, especially in males, providing more precise information, aiding the early diagnosis of emphysema and informing early intervention. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.