Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo

Darren Schofield, Lorraine Irving, Laura Calo, Anna Bogstedt, Gareth Rees, Annalisa Nuccitelli, Rajesh Narwal, Marcella Petrone, Jennifer Roberts, Lee Brown, Fiona Cusdin, Bhupinder Dosanjh, Christopher Lloyd, Claire Dobson, Ian Gurrell, Graham Fraser, Mary McFarlane, Edward Rockenstein, Brian Spencer, Eliezer Masliah, Maria Spillantini, Keith Tan, Andrew Billinton, Tris Vaughan, Iain Chessell, Michael Perkinton (2019) Preclinical development of a high affinity α-synuclein antibody, MEDI1341, that can enter the brain, sequester extracellular α-synuclein and attenuate α-synuclein spreading in vivo Neurobiol Dis (IF: 5.6) 132 104582

Links

http://www.ncbi.nlm.nih.gov/pubmed/31445162
http://dx.doi.org/10.1016/j.nbd.2019.104582

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