BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema
Pergakis, Badjatia, Chaturvedi, Cronin, Kimberly, Sheth, Simard (2019) BIIB093 (IV glibenclamide): an investigational compound for the prevention and treatment of severe cerebral edema Expert Opin Investig Drugs (IF: 4.9) 28(12) 1031-1040
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Abstract
Introduction: Brain swelling due to edema formation is a major cause of neurological deterioration and death in patients with large hemispheric infarction (LHI) and severe traumatic brain injury (TBI), especially contusion-TBI. Preclinical studies have shown that SUR1-TRPM4 channels play a critical role in edema formation and brain swelling in LHI and TBI. Glibenclamide, a sulfonylurea drug and potent inhibitor of SUR1-TRPM4, was reformulated for intravenous injection, known as BIIB093.Areas covered: We discuss the findings from Phase 2 clinical trials of BIIB093 in patients with LHI (GAMES-Pilot and GAMES-RP) and from a small Phase 2 clinical trial in patients with TBI. For the GAMES trials, we review data on objective biological variables, adjudicated edema-related endpoints, functional outcomes, and mortality which, despite missing the primary endpoint, supported the initiation of a Phase 3 trial in LHI (CHARM). For the TBI trial, we review data on MRI measures of edema and the initiation of a Phase 2 trial in contusion-TBI (ASTRAL).Expert opinion: Emerging clinical data show that BIIB093 has the potential to transform our management of patients with LHI, contusion-TBI and other conditions in which swelling leads to neurological deterioration and death.
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6893098http://www.ncbi.nlm.nih.gov/pubmed/31623469
http://dx.doi.org/10.1080/13543784.2019.1681967
