Dynamic Protein Allosteric Regulation and Disease
Nussinov, Tsai, Jang (2019) Dynamic Protein Allosteric Regulation and Disease Adv Exp Med Biol (IF: 3.7) 1163 25-43Abstract
Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level.
Links
http://www.ncbi.nlm.nih.gov/pubmed/31707698http://dx.doi.org/10.1007/978-981-13-8719-7_2
