Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis
Wang, Li, Jiang, Li, Zhang (2020) Effects of Bacterial Translocation and Autophagy on Acute Lung Injury Induced by Severe Acute Pancreatitis Gastroenterol Res Pract (IF: 2) 2020 8953453
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Abstract
To reveal the role of bacterial translocation (BT) and autophagy in severe acute pancreatitis-induced acute lung injury (SAP-ALI).Rats were separated into a control (sham-operation) group (n = 10) and a SAP group (n = 10) and a SAP group (.Levels of TNF-α, IL-6, lipase, and amylase in the SAP group were significantly higher than those in the control group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (P < 0.01). Histopathological score and W/D ratio of the lung in the SAP-BT(+) group were significantly higher than that in the SAP-BT(-) group (.BT can aggravate SAP-ALI with the increasing oxidative stress level, which may be related to the decrease of autophagy level.Copyright © 2020 Hanlin Wang et al.
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7040400http://www.ncbi.nlm.nih.gov/pubmed/32104173
http://dx.doi.org/10.1155/2020/8953453
