Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus
Ding, Xiao (2020) Gut microbiota: closely tied to the regulation of circadian clock in the development of type 2 diabetes mellitus Chin Med J (Engl) (IF: 6.1) 133(7) 817-825
Full text
Click the PDF icon to view the full text of the paper
Abstract
Type 2 diabetes mellitus (T2DM), a worldwide epidemic disease, has caused tremendous economic and social burden, but the pathogenesis remains uncertain. Nowadays, the impact of unrhythmic circadian clock caused by irregular sleep and unhealthy diet on T2DM has be increasingly studied. However, the contribution of the endogenous circadian clock system to the development of T2DM has not yet been satisfactorily explored. It is now becoming clear that the gut microbiota and the circadian clock interact with each other to regulate the host metabolism. Considering all these above, we reviewed the literature related to the gut microbiota, circadian clock, and T2DM to elucidate the idea that the gut microbiota is closely tied to the regulation of the circadian clock in the development of T2DM, which provides potential for gut microbiota-directed therapies to ameliorate the effects of circadian disruptions linked to the occurrence and development of T2DM.
Links
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147650http://www.ncbi.nlm.nih.gov/pubmed/32106122
http://dx.doi.org/10.1097/CM9.0000000000000702
