The Anti-lipopolysaccharide Factors in Crustaceans
Shihao Li, Fuhua Li (2020) The Anti-lipopolysaccharide Factors in Crustaceans Subcell Biochem 94 63-80Abstract
Anti-lipopolysaccharide factors (ALFs) are a type of antimicrobial peptide (AMP) which show broad-spectrum antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, fungi and viruses. In this chapter, we review the discovery and classification of this kind of antimicrobial peptide in crustaceans. The structure and function, as well as the mechanism of antibacterial and antiviral activities of ALFs will be summarized and discussed. We will then describe the expression and regulation of various ALF genes in different crustacean species. Finally, the application prospects of ALFs in drug development and disease-resistant genetic breeding will be pointed out and discussed. The review will also discuss several key questions such as the systematic classification and expression regulation of the ALF genes, as well as the future application of ALFs and ALF-derived peptides.
Links
http://www.ncbi.nlm.nih.gov/pubmed/32189296http://dx.doi.org/10.1007/978-3-030-41769-7_3
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