Th9 and Th17 cells: the controversial twins in cancer immunity

Yan, Richmond (2020) Th9 and Th17 cells: the controversial twins in cancer immunity J Clin Invest (IF: 15.9) 130(7) 3409-3411

Abstract

Th17 cells (producing IL-17) and Th9 cells (producing IL-9) exhibit functional plasticity, and their role in tumorigenicity is controversial. Th17/IL-17 and Th9/IL-9 exhibit critical, but often opposing, roles in tumor progression. In this issue of the JCI, Salazar et al. show that while IL-17 and IL-9 induced distinct but complementary molecular pathways, both cytokines also induced epithelial-mesenchymal transition (EMT) in lung cancer cells and promoted metastatic spreading. A key question before us now is whether IL-9 and IL-17 contribute to tumor progression in a sequential and stage-specific manner within the tumor microenvironment.

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324204
http://www.ncbi.nlm.nih.gov/pubmed/32484457
http://dx.doi.org/10.1172/JCI138418

Similar articles

Tools

Export to RIS