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Investigating developmental changes in scalp-to-cortex correspondence using diffuse optical tomography sensitivity in infancy.

Fu, Richards (2021) Investigating developmental changes in scalp-to-cortex correspondence using diffuse optical tomography sensitivity in infancy. Neurophotonics 8(3) 035003


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Abstract

Significance: Diffuse optical tomography (DOT) uses near-infrared light spectroscopy (NIRS) to measure changes in cerebral hemoglobin concentration. Anatomical interpretations of NIRS data require accurate descriptions of the cranio-cerebral relations and DOT sensitivity to the underlying cortical structures. Such information is limited for pediatric populations because they undergo rapid head and brain development. Aim: We aim to investigate age-related differences in scalp-to-cortex distance and mapping between scalp locations and cortical regions of interest (ROIs) among infants (2 weeks to 24 months with narrow age bins), children (4 and 12 years), and adults (20 to 24 years). Approach: We used spatial scalp projection and photon propagation simulation methods with age-matched realistic head models based on MRIs. Results: There were age-group differences in the scalp-to-cortex distances in infancy. The developmental increase was magnified in children and adults. There were systematic age-related differences in the probabilistic mappings between scalp locations and cortical ROIs. Conclusions: Our findings have important implications in the design of sensor placement and making anatomical interpretations in NIRS and fNIRS research. Age-appropriate, realistic head models should be used to provide anatomical guidance for standalone DOT data in infants.© 2021 The Authors.

意义:漫射光学断层扫描 (DOT) 使用近红外光谱 (NIRS) 来测量脑血红蛋白浓度的变化。 NIRS 数据的解剖学解释需要准确描述颅脑关系和 DOT 对底层皮质结构的敏感性。这些信息对于儿科人群来说是有限的,因为他们的头部和大脑发育很快。目的:我们旨在调查婴儿(2 周至 24 个月,年龄范围较窄)、儿童(4 岁和 12 岁)头皮到皮层距离的年龄相关差异以及头皮位置和皮层感兴趣区域 (ROI) 之间的映射。 ) 和成人(20 至 24 岁)。方法:我们使用空间头皮投影和光子传播模拟方法以及基于 MRI 的年龄匹配的真实头部模型。结果:婴儿期头皮到皮层的距离存在年龄组差异。儿童和成人的发育增长被放大。头皮位置和皮质 ROI 之间的概率映射存在系统的年龄相关差异。结论:我们的发现对传感器放置的设计以及在 NIRS 和 fNIRS 研究中进行解剖学解释具有重要意义。应使用适合年龄的真实头部模型为婴儿的独立 DOT 数据提供解剖指导。© 2021 作者。

Links

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8305752
http://www.ncbi.nlm.nih.gov/pubmed/34322572
http://dx.doi.org/10.1117/1.NPh.8.3.035003

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