Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities

Pei-Qian Wu, Yong-Sheng Cui, Xiao-Ying Han, Chen Wang, Pei-Pei An, Jun-Su Zhou, Yu-Hao Ren, Zhen-Long Liu, Rong-Tuan Lin, Bin Zhou, Jian-Min Yue (2022) Diterpenoids from Sauropus spatulifolius Leaves with Antimicrobial Activities J Nat Prod (IF: 3.6) 85(5) 1304-1314

Abstract

As a plant used in both food and medicine, Sauropus spatulifolius is consumed widely as a natural herbal tea, food source, and Chinese medicine. Inspired by its extensive applications, we conducted a systematic phytochemical study of the leaves of S. spatulifolius. Thirteen new diterpenoids, sauspatulifols A-M (1-13), including four ent-cleistanthane-type diterpenoids (1-4), eight 15,16-di-nor-ent-cleistanthane-type diterpenoids (5-12), and one 17-nor-ent-pimarane-type diterpenoid (13) as well as one known diterpenoid, cleistanthol (14), were isolated. All of these diterpenoids feature a 2α,3α-dihydroxy unit within the A ring, and their structures were elucidated by spectroscopic data analysis, electronic circular dichroism calculations, and single-crystal X-ray diffraction analysis. Compound 14 displayed moderate inhibitory activity against Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Shigella flexneri with the same minimum inhibitory concentration value of 12 μg/mL as well as activity against vesicular stomatitis virus and influenza A virus.

Links

http://www.ncbi.nlm.nih.gov/pubmed/35427111
http://dx.doi.org/10.1021/acs.jnatprod.2c00020

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